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Just this week we are noticing the same thing. Compact job starts at 3 am and compacts the log.nsf file. Long held lock dumps occur for 4 hours with queue lengths reaching > 40. By 7 am our users start to come in and say the system is slow and unresponsive.
Restarting always helps. We had the issue on Monday, then again on Thursday. Both times it was compacting the log.nsf file. The other days inbetween it never tried to compact the log.nsf file.
As a countermeasure today we had shutdown domino, renamed the log.nsf file. Added Log_DisableTXNLogging=1 to the notes.ini file and started Domino. Keeping fingers crossed.